Skin hyperpigmentation is a very common skin blemish that can be traced to the appearance of dark spots on the skin caused by the body's overproduction of melanin. Generally, the most affected parts of the body are the face, hands and other visible areas that are easily reached by sunlight.
Excessive melanin production is mainly determined by excessive exposure to the sun, but also by hormonal imbalances, specific diseases and certain medications.
The initial process of melanin production (melanogenesis) is controlled by tyrosinase, which is an enzyme that catalyzes the hydroxylation of tyrosine, the precursor of melanin, into dihydroxyphenylalanine (DOPA) and other intermediates.
Therefore, inhibition of tyrosinase activity or its production can prevent melanogenesis, and substances that can inhibit the activity of the tyrosine enzyme exert, therefore, a depigmenting-type action on spots.
DermaWHITE is a blend of bioactives developed in order to reduce skin hyperpigmentation.
- Extraction method: Naviglio extractor
- Application: skin care
- Action: depigmenting
Use level: 2%. - Inci*: Glycerin, Aqua, Arctostaphylos Uva-Ursi Leaf, Emblica Officinalis Fruit Extract, Glycyrrhiza glabra Root Extract, Pinus Pinaster Bark/Bud Extract, Abies Alba Seed Extract, Cucurbita Pepo Fruit Extract, Morus Alba leaf Extract, Punica Granatum Fruit Extract, Hordeum Vulgare Seed Extract, Origanum vulgare Extract, Phenoxyethanol, Potassium Sorbate, Sodium Benzoate, Citric Acid.
* Alternative preservative system:
– Benzyl Alcohol, Potassium Sorbate, Sodium Benzoate
– Citric acid, Potassium Sorbate, Sodium Benzoate
The efficacy of DermaWHITE was tested by in vitro tests.
Determination of depigmenting efficacy:
Tyrosinase enzyme inhibition.
Inhibition of the enzyme tyrosinase was determined using L-tyrosine as a substrate. This enzyme is involved in the natural development of skin, hair, and eye coloration and is also of particular relevance at the early stage in melanin synthesis. Substances capable of inhibiting this enzyme can be used in depigmenting skin treatments. The results were expressed in graph 1.
Based on the data obtained, DermaWHITE shows high ability to inhibit the tyrosinase enzyme.
Determination of depigmenting efficacy on reconstituted human epidermis in vitro.
The depigmenting and brightening effect was evaluated by using pigmented reconstructed human epidermis tissues composed of phototype VI keratinocytes and melanocytes located in the basal layer. The protocol involves induction of melanogenesis in the tissues by UV irradiation followed by treatment with the test sample.
The results, shown in Figure 2, highlighted the ability of DermaWHITE to reduce melanin production.
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